Co-founder
Mark TrifiroMD
Medicine & clinical translation
Physician-scientist with expertise in endocrinology, prostate cancer and the translation of nanomedicine research.
Preclinical oncology
Cancer treatment.Powered byphysics.
We are developing a new class of targeted therapeutics that use light-triggered energy release to physically destroy tumors.
Conceptual illustration
N10 TherapeuticsPrecision targetingControlled activationEnergetic ablation
The platform
Precision targeting meets
energetic ablation.
N10 combines tumor-targeting molecules, carbon nanotubes and an energetic payload in a modular nanotherapeutic. Near-infrared light is intended to trigger localized heat release within the treatment area.
Platform concept · Not to scale · Select a step to explore
A physical approach to a biological challenge.
Tumors can escape treatments that depend on a particular molecular pathway. N10 is developing an approach in which heat delivers the final tumor-killing effect.
Control over where treatment acts
Targeting and illumination are designed to work together to focus energy release within the intended treatment area.
Greater local heat generation
The energetic payload is designed to amplify heating, with the goal of reducing the laser energy required for tumor ablation.
Our lead program
Starting with
prostate cancer.
Our lead program explores PSMA-targeted energetic nanotherapy for localized prostate cancer. We are developing antibody targeting approaches alongside a laser-activated formulation for focal tumor ablation.
A modular platform. Our longer-term aim is to adapt the targeting component for other solid tumors. Research priorities include thermal control, tumor selectivity and the potential for antitumor immune responses.
The scientific founders
Built by the scientists
behind the platform.
Bringing cancer biology, translational medicine and energetic materials together.
Co-founder
Miltiadis PaliourasPhD
Cancer biology & nanomedicine
Cancer researcher with experience in prostate and breast cancer biology, targeted nanotherapies and molecular diagnostics.
Co-founder
Davin G. PierceyPhD
Energetic materials
Chemist specializing in nitrogen-rich energetic materials and the relationship between molecular structure and energy release.
Connect with N10
Help bring a new
approach to cancer.
We welcome conversations with research collaborators, development partners and investors.
Contact N10contact@n10.bio